FASUDIL-103745-39-7-C14H19Cl2N3O2S -Chemindustry.com - The leading vertical market advertising source for the chemical world

CAS No.: 103745-39-7 Formula: C14H19Cl2N3O2S

Weight: 364.29100

Synonyms: Fasudilum; Fasudilum [inn-latin]; H-1077 dihydrochloride; hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine; at877; HA-1077 DIHYDROCHLORIDE NOVEL VASODILATO R AGE; 1-(5-isoquinolinesulphonyl)-homopiperazine; 1-(5-ISOQUINOLINE-SULFONYL)-HOMOPIPERAZINE; HA 1077,DIHYDROCHLORIDE; 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine,Dihydrochloride;

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Description

A potent calcium antagonist vasodilator which is considered to act by employing different mechanisms from the usual calcium channel blockers since it inhibits (1) calcium ionophore A23187 induced contraction in arterial strips and (2) phenylephrine induced contraction in calcium free media suggesting that its site of action is in the intracellular space. Also reported to potently inhibit Rho-associated Kinase (ROCK IC50= 10.7 uM).

Basic Information

CAS No.:

103745-39-7

Synonyms:

Fasudilum; Fasudilum [inn-latin]; H-1077 dihydrochloride; hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine; at877; HA-1077 DIHYDROCHLORIDE NOVEL VASODILATO R AGE; 1-(5-isoquinolinesulphonyl)-homopiperazine; 1-(5-ISOQUINOLINE-SULFONYL)-HOMOPIPERAZINE; HA 1077,DIHYDROCHLORIDE; 1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine,Dihydrochloride;

Formula:

C14H19Cl2N3O2S

Molecular Weight:

364.29100

PSA:

70.68000

LogP:

4.17030

Properties

Appearance & Character:

White crystalline Solid

Density:

1.289g/cm3

Melting Point:

Boiling Point:

506.2ºC at 760mmHg

Flash Point:

259.9ºC

Storage Conditions:

Safety Info

Customs Code:

2933990090

WGK Germany:

3